Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron

The consumption of red meat is probably carcinogenic to humans and is associated with an increased risk to develop colorectal cancer (CRC). Red meat contains high amounts of heme iron, which is thought to play a causal role in tumor formation. In this study, we investigated the genotoxic and cytotox...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Seiwert, Nina, Wecklein, Sabine, Demuth, Philipp, Hasselwander, Solveig, Kemper, Talke A., Schwerdtle, Tanja, Brunner, Thomas, Fahrer, Jörg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511955/
https://ncbi.nlm.nih.gov/pubmed/32968051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02950-8
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