Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma

Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in patients with cutaneous melanoma (CM), assess th...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Cubillos-Zapata, Carolina, Martínez-García, Miguel Ángel, Díaz-García, Elena, Jaureguizar, Ana, Campos-Rodríguez, Francisco, Sánchez-de-la-Torre, Manuel, Nagore, Eduardo, Martorell-Calatayud, Antonio, Blasco, Luis Hernández, Pastor, Esther, Abad-Capa, Jorge, Montserrat, Josep María, Cabriada-Nuño, Valentín, Cano-Pumarega, Irene, Corral-Peñafiel, Jaime, Arias, Eva, Mediano, Olga, Somoza-González, María, Dalmau-Arias, Joan, Almendros, Isaac, Farré, Ramón, López-Collazo, Eduardo, Gozal, David, García-Río, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511355/
https://ncbi.nlm.nih.gov/pubmed/32968152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72481-x
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