Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Lesions of MF are formed by hematogenous seeding the skin with polyclonal (clonotypically diverse) neoplastic T-cells which accumulate numerous mutations and display a high degree of mutational, intratumoral heterogeneity (ITH). A...

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Udgivet i:Sci Rep
Main Authors: Iyer, Aishwarya, Hennessey, Dylan, O’Keefe, Sandra, Patterson, Jordan, Wang, Weiwei, Wong, Gane Ka-Shu, Gniadecki, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511331/
https://ncbi.nlm.nih.gov/pubmed/32968137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72459-9
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