Clonotypic heterogeneity in cutaneous T-cell lymphoma (mycosis fungoides) revealed by comprehensive whole-exome sequencing

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is believed to represent a clonal expansion of a transformed skin-resident memory T cell. T-cell receptor (TCR) clonality (ie, identical sequences of rearranged TCRα, TCRβ, and TCRγ), the key premise of this hypothesis, has b...

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Udgivet i:Blood Adv
Main Authors: Iyer, Aishwarya, Hennessey, Dylan, O’Keefe, Sandra, Patterson, Jordan, Wang, Weiwei, Salopek, Thomas, Wong, Gane Ka-Shu, Gniadecki, Robert
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457216/
https://ncbi.nlm.nih.gov/pubmed/30967393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027482
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