Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, wheth...

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Publicat a:eLife
Autors principals: Zhang, Jie, Song, Lihong, Pedersen, Dennis V, Li, Anna, Lambris, John D, Andersen, Gregers Rom, Mollnes, Tom Eirik, Ma, Ying Jie, Garred, Peter
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Immunology and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511233/
https://ncbi.nlm.nih.gov/pubmed/32909942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60908
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