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Elemental quantification and analysis of structural abnormalities in neurons from Parkinson’s-diseased brains by X-ray fluorescence microscopy and diffraction

In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls. A total of 53 neurons were analyzed with X-ray fluorescence (XRF) and diffraction using sub-µm-focused s...

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Detalhes bibliográficos
Publicado no:Biomed Opt Express
Main Authors: Joppe, Karina, Nicolas, Jan-David, Grünewald, Tilman A., Eckermann, Marina, Salditt, Tim, Lingor, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Optical Society of America 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510930/
https://ncbi.nlm.nih.gov/pubmed/33014542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1364/BOE.389408
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