Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling

S-glutathionylation of reactive protein cysteines is a post-translational event that plays a critical role in transducing signals from oxidants into biological responses. S-glutathionylation can be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). We have previously demonstrated that a...

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Udgivet i:Redox Biol
Main Authors: Chia, Shi B., Nolin, James D., Aboushousha, Reem, Erikson, Cuixia, Irvin, Charles G., Poynter, Matthew E., van der Velden, Jos, Taatjes, Douglas J., van der Vliet, Albert, Anathy, Vikas, Janssen-Heininger, Yvonne M.W.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509797/
https://ncbi.nlm.nih.gov/pubmed/32971362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101720
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