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Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis
Myeloperoxidase (MPO)-derived hypochlorous (HOCl) reacts with membrane plasmalogens to yield α-chlorofatty aldehydes such as 2-chlorofatty aldehyde (2-ClFALD) and its metabolite 2-chlorofatty acid (2-ClFA). Recent studies showed that 2-ClFALD and 2-ClFA serve as mediators of the inflammatory respons...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7509276/ https://ncbi.nlm.nih.gov/pubmed/32762560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00440.2020 |
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