A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics and quality control remain unexplored. He...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Cerqueira, Fernanda M., von Stockum, Sophia, Giacomello, Marta, Goliand, Inna, Kakimoto, Pamela, Marchesan, Elena, De Stefani, Diego, Kowaltowski, Alicia J., Ziviani, Elena, Shirihai, Orian S.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509235/
https://ncbi.nlm.nih.gov/pubmed/32956978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101676
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