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A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation

Polycomb and Trithorax group proteins maintain stable epigenetic memory of gene expression states for some genes, but many targets show highly dynamic regulation. Here we combine experiment and theory to examine the mechanistic basis of these different modes of regulation. We present a mathematical...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Reinig, Jeannette, Ruge, Frank, Howard, Martin, Ringrose, Leonie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508846/
https://ncbi.nlm.nih.gov/pubmed/32963223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18507-4
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