Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats

Endogenous cardiotonic steroid, marinobufagenin (MBG), induces Fli1-dependent tissue fibrosis. We hypothesized that an increase in MBG initiates the development of aortic fibrosis in salt-loaded rats with type 2 diabetes mellitus (DM2) via pressure-independent mechanism. DM2 was induced by a single...

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Detalhes bibliográficos
Publicado no:J Cardiovasc Pharmacol
Main Authors: Fedorova, Olga V., Fadeev, Artem V., Grigorova, Yulia N., Marshall, Courtney A., Zernetkina, Valentina, Kolodkin, Nikolai I., Agalakova, Natalia I., Konradi, Alexandra O., Lakatta, Edward G., Bagrov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508669/
https://ncbi.nlm.nih.gov/pubmed/31415452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000730
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