Preserved Efficacy and Reduced Toxicity with Intermittent Linezolid Dosing in Combination with Bedaquiline and Pretomanid in a Murine Tuberculosis Model

The novel regimen of bedaquiline, pretomanid, and linezolid (BPaL) is highly effective against drug-resistant tuberculosis, but linezolid toxicities are frequent. We hypothesized that, for a similar total weekly cumulative dose, thrice-weekly administration of linezolid would preserve efficacy while...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Bigelow, Kristina M., Tasneen, Rokeya, Chang, Yong S., Dooley, Kelly E., Nuermberger, Eric L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508620/
https://ncbi.nlm.nih.gov/pubmed/32690647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01178-20
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items