Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism

BACKGROUND: Myocardial ischemia/reperfusion (MI/R) injury imposes devastating cardiovascular sequelae in particular cardiac dysfunction as a result of restored blood flow. However, the mechanism behind MI/R injury remains elusive. Mitochondrial ubiquitin ligase (MITOL/MARCH5) is localized at the mit...

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Bibliografski detalji
Izdano u:Clin Transl Med
Glavni autori: Lu, Linhe, Ma, Jipeng, Tang, Jiayou, Liu, Yang, Zheng, Qijun, Chen, Shasha, Gao, Erhe, Ren, Jun, Yang, Lifang, Yang, Jian
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507588/
https://ncbi.nlm.nih.gov/pubmed/32997406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.166
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