Importance of the Immunodominant CD8(+) T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection

The circumsporozoite protein (CSP) builds up the surface coat of sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate. CSP has been shown to induce robust CD8(+) T cell responses that are capable of eliminating developing parasites in hepatocytes, resulting in protective i...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Gibbins, Matthew P., Müller, Katja, Glover, Maya, Liu, Jasmine, Putrianti, Elyzana D., Bauza, Karolis, Reyes-Sandoval, Arturo, Matuschewski, Kai, Silvie, Olivier, Hafalla, Julius Clemence R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504970/
https://ncbi.nlm.nih.gov/pubmed/32719159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00383-20
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