Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

The adenylate cyclase toxoid (ACT) of Bordetella pertussis is capable of delivering its N-terminal catalytic domain into the cytosol of CD11b-expressing professional antigen-presenting cells such as myeloid dendritic cells. This allows delivery of CD8(+) T-cell epitopes to the major histocompatibili...

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Main Authors: Tartz, Susanne, Kamanova, Jana, Simsova, Marcela, Sebo, Peter, Bolte, Stefanie, Heussler, Volker, Fleischer, Bernhard, Jacobs, Thomas
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2006
Ábhair:
Fungal and Parasitic Infections
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418933/
https://ncbi.nlm.nih.gov/pubmed/16552058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.4.2277-2285.2006
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