Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway

Thalidomide exerts its teratogenic and immunomodulatory effects by binding to cereblon (CRBN) and thereby inhibiting/modifying the CRBN-mediated ubiquitination pathway consisting of the Cullin4-DDB1-ROC1 E3 ligase complex. The mechanism of thalidomide’s classical hypnotic effect remains largely unex...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hirose, Yuki, Kitazono, Tomohiro, Sezaki, Maiko, Abe, Manabu, Sakimura, Kenji, Funato, Hiromasa, Handa, Hiroshi, Vogt, Kaspar E., Yanagisawa, Masashi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502749/
https://ncbi.nlm.nih.gov/pubmed/32848052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917701117
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