Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The drive system targets the cardinal gene ortholog producing a red-eye phenotype. Drive can achieve 98 to 100% in both sexes and full intr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Carballar-Lejarazú, Rebeca, Ogaugwu, Christian, Tushar, Taylor, Kelsey, Adam, Pham, Thai Binh, Murphy, Jazmin, Schmidt, Hanno, Lee, Yoosook, Lanzaro, Gregory C., James, Anthony A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502704/
https://ncbi.nlm.nih.gov/pubmed/32839345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010214117
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