Genetic characterization of three distinct mechanisms supporting RNA-driven DNA repair and modification reveals major role of DNA polymerase ζ

DNA double-strand breaks (DSBs) are dangerous lesions threatening genomic stability. Fidelity of DSB repair is best achieved by recombination with a homologous template sequence. In yeast, transcript RNA was shown to template DSB repair of DNA. However, molecular pathways of RNA-driven repair proces...

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Publicado en:Mol Cell
Main Authors: Meers, Chance, Keskin, Havva, Banyai, Gabor, Mazina, Olga, Yang, Taehwan, Gombolay, Alli L., Mukherjee, Kuntal, Kaparos, Efiyenia I., Newnam, Gary, Mazin, Alexander, Storici, Francesca
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502545/
https://ncbi.nlm.nih.gov/pubmed/32882183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.011
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