Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression

Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In this study, we determined the effect of relatively s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Caiment, F., Wolters, J., Smit, E., Schrooders, Y., Kleinjans, J., van den Beucken, T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2020
Pynciau:
Molecular Toxicology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502062/
https://ncbi.nlm.nih.gov/pubmed/32623605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02835-x
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