Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

[Image: see text] Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The aim of this study is to further investigate VPA-induced mechanisms of...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Wolters, Jarno E. J., van Breda, Simone G. J., Caiment, Florian, Claessen, Sandra M., de Kok, Theo M. C. M., Kleinjans, Jos C. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645762/
https://ncbi.nlm.nih.gov/pubmed/28853863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00171
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