Identification of an anti-diabetic, orally available, small molecule that regulates TXNIP expression and glucagon action

Diabetes is characterized by hyperglycemia, loss of functional islet beta-cell mass, deficiency of glucose-lowering insulin and persistent alpha-cell secretion of gluconeogenic glucagon. Still, no therapies that target these underlying processes are available. We therefore performed high-throughput...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Thielen, Lance A., Chen, Junqin, Jing, Gu, Moukha-Chafiq, Omar, Xu, Guanlan, Jo, SeongHo, Grayson, Truman B., Lu, Brian, Li, Peng, Augelli-Szafran, Corinne E., Suto, Mark J., Kanke, Matt, Sethupathy, Praveen, Kim, Jason K., Shalev, Anath
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501995/
https://ncbi.nlm.nih.gov/pubmed/32726606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.07.002
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