Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians

BACKGROUND: Obesity and energy expenditure (EE) are heritable and genetic variants influencing EE may contribute to the development of obesity. We sought to identify genetic variants that affect EE in American Indians, an ethnic group with high prevalence of obesity. METHODS: Whole-exome sequencing...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Piaggi, Paolo, Köroğlu, Çiğdem, Nair, Anup K, Sutherland, Jeff, Muller, Yunhua L, Kumar, Pankaj, Hsueh, Wen-Chi, Kobes, Sayuko, Shuldiner, Alan R, Kim, Hye In, Gosalia, Nehal, Van Hout, Cristopher V, Jones, Marcus, Knowler, William C, Krakoff, Jonathan, Hanson, Robert L, Bogardus, Clifton, Baier, Leslie J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501742/
https://ncbi.nlm.nih.gov/pubmed/32818236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgaa548
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