Direct suppression of human islet dedifferentiation, progenitor genes, but not epithelial to mesenchymal transition by liraglutide

β-cell dedifferentiation has been accounted as one of the major mechanisms for β-cell failure; thus, is a cause to diabetes. We study direct impacts of liraglutide treatment on ex vivo human dedifferentiated islets, and its effects on genes important in endocrine function, progenitor states, and epi...

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Bibliografiske detaljer
Udgivet i:Heliyon
Main Authors: Rattanaamnuaychai, Pimploy, Roshorm, Yaowaluck Maprang, Wilasrusmee, Chumpon, Proprom, Napaphat, Ongphiphadhanakul, Boonsong, Talchai, Shivatra Chutima
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501427/
https://ncbi.nlm.nih.gov/pubmed/32995630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e04951
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