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Lysine Oxidase Exposes a Dependency on the Thioredoxin Antioxidant Pathway in Triple-Negative Breast Cancer Cells
PURPOSE: Transformed cells are vulnerable to depletion of certain amino acids. Lysine oxidase (LO) catalyzes the oxidative deamination of lysine, resulting in lysine depletion and hydrogen peroxide production. Although LO has broad antitumor activity in preclinical models, the cytotoxic mechanisms o...
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| Publicado no: | Breast Cancer Res Treat |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501192/ https://ncbi.nlm.nih.gov/pubmed/32696316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-020-05801-4 |
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