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Metformin Sensitizes Triple-Negative Breast Cancer to Proapoptotic TRAIL Receptor Agonists by Suppressing XIAP Expression
PURPOSE: Despite robust antitumor activity in diverse preclinical models, TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists have not demonstrated efficacy in clinical trials, underscoring the need to identify agents that enhance their activity. We postulated that the metabolic stress i...
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| Publicado no: | Breast Cancer Res Treat |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544153/ https://ncbi.nlm.nih.gov/pubmed/28324269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-017-4201-0 |
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