Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

BACKGROUND: Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease. RESULTS: To decipher connections between these processes, we create LostArc, an ultrasensit...

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Bibliografski detalji
Izdano u:Genome Biol
Glavni autori: Lujan, Scott A., Longley, Matthew J., Humble, Margaret H., Lavender, Christopher A., Burkholder, Adam, Blakely, Emma L., Alston, Charlotte L., Gorman, Grainne S., Turnbull, Doug M., McFarland, Robert, Taylor, Robert W., Kunkel, Thomas A., Copeland, William C.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500033/
https://ncbi.nlm.nih.gov/pubmed/32943091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02138-5
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