Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer

Anlotinib (AL3818), a novel multi-targeted receptor tyrosine kinase inhibitor, has recently been proven to be an antitumour drug. This study aimed to explore the antitumour effect of anlotinib and its underlying molecular mechanisms in human pancreatic cancer (PC) cells. The anti-proliferative effec...

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Vydáno v:Cell Death Dis
Hlavní autoři: Yang, Liguo, Zhou, Xiaoshu, Sun, Jinrui, Lei, Qianghui, Wang, Qi, Pan, Di, Ding, Mingxing, Ding, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499216/
https://ncbi.nlm.nih.gov/pubmed/32943607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02938-4
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