Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS

Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with the influenza virus (H1N1) and obviously aggravated...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Luo, Zhuo, Liu, Li-Fang, Jiang, Ying-Nan, Tang, Lu-Ping, Li, Wen, Ouyang, Shu-Hua, Tu, Long-Fang, Wu, Yan-Ping, Gong, Hai-Biao, Yan, Chang-Yu, Jiang, Shan, Lu, Yu-Hui, Liu, Tongzheng, Jiang, Zhenyou, Kurihara, Hiroshi, Yu, Yang, Yao, Xin-Sheng, Li, Yi-Fang, He, Rong-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499204/
https://ncbi.nlm.nih.gov/pubmed/32943610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00238-z
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