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Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics
Abemaciclib is an oral anticancer drug that inhibits cyclin dependent kinases 4 and 6 and is metabolized by cytochrome P450 3A in the intestines and liver to active metabolites. The objectives were (1) to develop a mechanistic model to characterize the pharmacokinetics (PK) of the active moieties an...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7499187/ https://ncbi.nlm.nih.gov/pubmed/32683787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12544 |
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