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Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding
Quantifying chemical substituent contributions to ligand-binding free energies is challenging due to nonadditive effects. Protein allostery is a frequent cause of nonadditivity, but the underlying allosteric mechanisms often remain elusive. Here, we propose a general NMR-based approach to elucidate...
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| 發表在: | Biophys J |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7499118/ https://ncbi.nlm.nih.gov/pubmed/32882185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.07.038 |
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