Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability. Arginine, the substrate for NO production, becomes acutely deficient in SCD patients with vaso-occlusive pain episodes (VOE). To determine if arginine improves mitochondrial func...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Morris, Claudia R., Brown, Lou Ann S., Reynolds, Michael, Dampier, Carlton D., Lane, Peter A., Watt, Amanda, Kumari, Polly, Harris, Frank, Manoranjithan, Shaminy, Mendis, Reshika D., Figueroa, Janet, Shiva, Sruti
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2020
Pynciau:
Clinical Trials and Observations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498366/
https://ncbi.nlm.nih.gov/pubmed/32384147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003672
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