Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

Altered mitochondrial function occurs in sickle cell disease (SCD), due in part to low nitric oxide (NO) bioavailability. Arginine, the substrate for NO production, becomes acutely deficient in SCD patients with vaso-occlusive pain episodes (VOE). To determine if arginine improves mitochondrial func...

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Veröffentlicht in:Blood
Hauptverfasser: Morris, Claudia R., Brown, Lou Ann S., Reynolds, Michael, Dampier, Carlton D., Lane, Peter A., Watt, Amanda, Kumari, Polly, Harris, Frank, Manoranjithan, Shaminy, Mendis, Reshika D., Figueroa, Janet, Shiva, Sruti
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498366/
https://ncbi.nlm.nih.gov/pubmed/32384147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003672
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