Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation

Human Y-box binding protein 1 (YB-1) is a multifunctional protein and overexpressed in many types of cancer. It specifically recognizes DNA/RNA through a cold shock domain (CSD) and regulates nucleic acid metabolism. The C-terminal extension of CSD and the phosphorylation of S102 are indispensable f...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Zhang, Jingfeng, Fan, Jing-Song, Li, Shuangli, Yang, Yunhuang, Sun, Peng, Zhu, Qinjun, Wang, Jiannan, Jiang, Bin, Yang, Daiwen, Liu, Maili
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498358/
https://ncbi.nlm.nih.gov/pubmed/32710623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa619
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