The Cold Shock Domain of YB-1 Segregates RNA from DNA by Non-Bonded Interactions

The human YB-1 protein plays multiple cellular roles, of which many are dictated by its binding to RNA and DNA through its Cold Shock Domain (CSD). Using molecular dynamics simulation approaches validated by experimental assays, the YB1 CSD was found to interact with nucleic acids in a sequence-depe...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kljashtorny, Vladislav, Nikonov, Stanislav, Ovchinnikov, Lev, Lyabin, Dmitry, Vodovar, Nicolas, Curmi, Patrick, Manivet, Philippe
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493011/
https://ncbi.nlm.nih.gov/pubmed/26147853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130318
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