13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the phosphatidylinositol 3-kinase/AKT-, RAS/MAPK-, and STAT5-signaling pathways. In this study, we...

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Bibliographic Details
Published in:Blood
Main Authors: Yang, Minjun, Safavi, Setareh, Woodward, Eleanor L., Duployez, Nicolas, Olsson-Arvidsson, Linda, Ungerbäck, Jonas, Sigvardsson, Mikael, Zaliova, Marketa, Zuna, Jan, Fioretos, Thoas, Johansson, Bertil, Nord, Karolin H., Paulsson, Kajsa
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498303/
https://ncbi.nlm.nih.gov/pubmed/32384149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004684
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