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Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists

[Image: see text] The most challenging step in the preparation of many opioid antagonists is the selective N-demethylation of a 14-hydroxymorphinan precursor. This process is carried out on a large scale using stoichiometric amounts of hazardous chemicals like cyanogen bromide or chloroformates. We...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Glotz, Gabriel, Kappe, C. Oliver, Cantillo, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498191/
https://ncbi.nlm.nih.gov/pubmed/32790319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02424
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