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Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists
[Image: see text] The most challenging step in the preparation of many opioid antagonists is the selective N-demethylation of a 14-hydroxymorphinan precursor. This process is carried out on a large scale using stoichiometric amounts of hazardous chemicals like cyanogen bromide or chloroformates. We...
Tallennettuna:
| Julkaisussa: | Org Lett |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Chemical
Society
2020
|
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7498191/ https://ncbi.nlm.nih.gov/pubmed/32790319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02424 |
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