Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists

One of the strategies employed by novel anticancer therapies is to put the process of apoptosis back on track by blocking the interaction between inhibitor of apoptosis proteins (IAPs) and caspases. The activity of caspases is modulated by the caspases themselves in a caspase/procaspase proteolytic...

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Bibliografske podrobnosti
izdano v:Invest New Drugs
Main Authors: Łupicka-Słowik, Agnieszka, Psurski, Mateusz, Grzywa, Renata, Cuprych, Monika, Ciekot, Jarosław, Goldeman, Waldemar, Wojaczyńska, Elżbieta, Wojaczyński, Jacek, Oleksyszyn, Józef, Sieńczyk, Marcin
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2020
Teme:
Preclinical Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497679/
https://ncbi.nlm.nih.gov/pubmed/32270379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-020-00923-4
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