Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation

Dexamethasone (Dex), a widely prescribed anti-inflammatory drug, was reported to induce liver enlargement (hepatomegaly) in clinical practice and in animal models. However, the underlying mechanisms are not elucidated. Dex is a known activator of pregnane X receptor (PXR). Yes-associated protein (YA...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Jiao, Tingying, Yao, Xinpeng, Zhao, Yingyuan, Zhou, Yanying, Gao, Yue, Fan, Shicheng, Chen, Panpan, Li, Xuan, Jiang, Yiming, Yang, Xiao, Gonzalez, Frank J., Huang, Min, Bi, Huichang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497622/
https://ncbi.nlm.nih.gov/pubmed/32561593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000061
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