Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric Fe(II) metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity against colon cancer cells (HCT116 p53(+/+)) with r...

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Bibliografski detalji
Izdano u:Angew Chem Int Ed Engl
Glavni autori: Song, Hualong, Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah E., Kasparkova, Jana, Kostrhunova, Hana, Novohradsky, Vojtech, Phillips, Roger M., Pracharova, Jitka, Rogers, Nicola J., Shepherd, Samantha L., Scott, Peter
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497174/
https://ncbi.nlm.nih.gov/pubmed/32489012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006814
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