Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Helicates and related metallofoldamers, synthesised by dynamic self-assembly, represent an area of chemical space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-soluble, optically pure Fe(ii)- and even Zn(ii)-base...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Song, Hualong, Rogers, Nicola J., Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah, Kostrhunova, Hana, Markova, Lenka, Phillips, Roger M., Pinder, Emma C., Shepherd, Samantha L., Young, Lawrence S., Zajac, Juraj, Scott, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839601/
https://ncbi.nlm.nih.gov/pubmed/31803429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02651g
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