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Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function

Peficitinib (ASP015K) is a novel Janus kinase inhibitor developed for the treatment of rheumatoid arthritis (RA). The impact of hepatic impairment on the peficitinib pharmacokinetic (PK) and safety profile was investigated in non‐RA subjects (n = 24) in an open‐label, parallel‐group, multicenter com...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Drug Dev
Main Authors: Miyatake, Daisuke, Shibata, Tomohisa, Toyoshima, Junko, Kaneko, Yuichiro, Oda, Kazuo, Nishimura, Tetsuya, Katashima, Masataka, Sakaki, Masashi, Inoue, Kazuaki, Ito, Takayoshi, Uchida, Naoki, Furihata, Kenichi, Urae, Akinori
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496893/
https://ncbi.nlm.nih.gov/pubmed/31833184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.751
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