Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function

Peficitinib (ASP015K) is a novel Janus kinase inhibitor developed for the treatment of rheumatoid arthritis (RA). The impact of hepatic impairment on the peficitinib pharmacokinetic (PK) and safety profile was investigated in non‐RA subjects (n = 24) in an open‐label, parallel‐group, multicenter com...

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Publicado no:Clin Pharmacol Drug Dev
Main Authors: Miyatake, Daisuke, Shibata, Tomohisa, Toyoshima, Junko, Kaneko, Yuichiro, Oda, Kazuo, Nishimura, Tetsuya, Katashima, Masataka, Sakaki, Masashi, Inoue, Kazuaki, Ito, Takayoshi, Uchida, Naoki, Furihata, Kenichi, Urae, Akinori
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496893/
https://ncbi.nlm.nih.gov/pubmed/31833184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.751
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