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Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5

The implication of complement in multiple diseases over the last 20 years has fuelled interest in developing anti‐complement drugs. To date, the focus has been on C5; blocking cleavage of C5 prevents formation of two pro‐inflammatory activities, C5a anaphylatoxin and membrane attack complex. The con...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Zelek, Wioleta M., Menzies, Georgina E., Brancale, Andrea, Stockinger, Brigitta, Morgan, Bryan Paul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496778/
https://ncbi.nlm.nih.gov/pubmed/32557571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13228
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