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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results e...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Tsiamantas, Christos, Kwon, Sunbum, Rogers, Joseph M., Douat, Céline, Huc, Ivan, Suga, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496375/
https://ncbi.nlm.nih.gov/pubmed/31894626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914654
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