Implantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease

Huntington's disease (HD) is a devastating, autosomal‐dominant neurodegenerative disease, for which there are currently no disease‐modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the past two decades but have met with only...

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Publicado en:Stem Cells
Autores principales: Yoon, Yongwoo, Kim, Hyun Sook, Jeon, Iksoo, Noh, Jeong‐Eun, Park, Hyun Jung, Lee, Suji, Park, In‐Hyun, Stevanato, Lara, Hicks, Caroline, Corteling, Randolph, Barker, Roger A., Sinden, John D., Song, Jihwan
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Regenerative Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496241/
https://ncbi.nlm.nih.gov/pubmed/32374064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3191
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