Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events

A mycoplasma contamination event in a biomanufacturing facility can result in costly cleanups and potential drug shortages. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and penetrate the standard 0.2‐µm filters used in the clarification of harvested cell...

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Bibliografiske detaljer
Udgivet i:Biotechnol Bioeng
Main Authors: Fratz‐Berilla, Erica J., Angart, Phillip, Graham, Ryan J., Powers, David N., Mohammad, Adil, Kohnhorst, Casey, Faison, Talia, Velugula‐Yellela, Sai Rashmika, Trunfio, Nicholas, Agarabi, Cyrus
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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ARTICLES
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496122/
https://ncbi.nlm.nih.gov/pubmed/32436993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27436
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