SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells

SHOC2 scaffold protein has been mainly related to oncogenic ERK signaling through the RAS-SHOC2-PP1 phosphatase complex. In leukemic cells however, SHOC2 upregulation has been previously related to an increased 5-year event-free survival of pediatric pre-B acute lymphoid leukemia, suggesting that SH...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Silveira, Vanessa Silva, Borges, Kleiton Silva, Santos, Verena Silva, Ruckert, Mariana Tannús, Vieira, Gabriela Maciel, Vasconcelos, Elton José Rosas, Nagano, Luis Fernando Peinado, Tone, Luiz Gonzaga, Scrideli, Carlos Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495473/
https://ncbi.nlm.nih.gov/pubmed/32938995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72124-1
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