Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential

H7N9 avian influenza viruses (AIVs) continue to evolve and remain a huge threat to human health and the poultry industry. Previously, serially passaging the H7N9 A/Anhui/1/2013 virus in the presence of homologous ferret antiserum resulted in immune escape viruses containing amino acid substitutions...

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Vydáno v:J Virol
Hlavní autoři: Chang, Pengxiang, Sealy, Joshua E., Sadeyen, Jean-Remy, Bhat, Sushant, Lukosaityte, Deimante, Sun, Yipeng, Iqbal, Munir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495387/
https://ncbi.nlm.nih.gov/pubmed/32699084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00216-20
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