Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus

Regulatory T cells (Tregs) may be key contributors to the HIV/SIV latent reservoir, since they harbor high levels of HIV/SIV; reverse CD4(+) T cell immune activation status, increasing the pool of resting CD4(+) T cells; and impair CD8(+) T cell function, favoring HIV persistence. We tested the hypo...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Sivanandham, Ranjit, Kleinman, Adam J., Sette, Paola, Brocca-Cofano, Egidio, Kilapandal Venkatraman, Sindhuja Murali, Policicchio, Benjamin B., He, Tianyu, Xu, Cuiling, Swarthout, Julia, Wang, Zhirui, Pandrea, Ivona, Apetrei, Cristian
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495362/
https://ncbi.nlm.nih.gov/pubmed/32669326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00533-20
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