X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development

HUWE1 is a HECT-domain ubiquitin E3 ligase expressed in various tissues. Although HUWE1 is known to promote degradation of the tumor suppressor p53, given a growing list of its substrates, in vivo functions of HUWE1 remain elusive. Here, we investigated the role of HUWE1 in the female reproductive s...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Eisa, Alaa A., Bang, Scott, Crawford, Katherine J., Murphy, Emily M., Feng, William W., Dey, Souvik, Wells, Wendy, Kon, Ning, Gu, Wei, Mehlmann, Lisa M., Vijayaraghavan, Srinivasan, Kurokawa, Manabu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495106/
https://ncbi.nlm.nih.gov/pubmed/32927266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101523
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